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. This suggests a partition of the folding space into "rapid" dimensions representing the local formation of secondary structure, and "slow" dimensions representing the topomer search
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. Before use, the eggs were thoroughly washed with distilled water and suspended in phosphate buffered saline (PBS) solution
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. In the diffusion spFRET measurements described in this article, by labeling the ends of the loop-bearing arms with donor and acceptor dyes, we use the FRET efficiency E as an indicator of the distance between arms A and B of the ribozyme during the docking process
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