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The addition of PEP alone slightly destabilized the protein (Table 3), suggesting that the conformational changes monitored by trypsin digestion and quenching experiments did not result in large thermodynamic variations
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Büldt (Forschungszentrum Jülich) for continuous support in his institute
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Figure 11 represents the morphology of Sn-Ag-Cu-Bi solder after dipping the Cu and Ni substrate into it
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Hard spheres with surface adhesion: the Percus-Yevick approximation and the energy equation
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To enable characterization of different conformational states of TTR, we employed four different molecular probes: ANS, 4-4-bis-1-phenylamino-8-naphthalene sulfonate (Bis-ANS), 4-(dicyanovinyl)-julolidine (DCVJ), and thioflavin T (ThT) (Fig
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High-resolution probing of local conformational changes in proteins by the use of multiple labeling: unfolding and selfassembly of human carbonic anhydrase II monitored by spin, fluorescent, and chemical reactivity probes
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This suggests different modes of lipid-protein interactions in plasma spherical and model discoidal HDL, which may result from different chemical composition and/or geometry of these particles
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According to the polymeric paradigm (Fändrich and Dobson, 2002) of amyloidogenesis and the therein-implicated importance of backbone interactions, the more the native structure becomes distorted (and the protein backbone becomes exposed), the higher the chance that the protein steps onto the amyloidogenic pathway
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An attempt to articulate a range of scenarios in which partial ordering of secondary and tertiary structures mutually enhance a favorable folding pathway has been presented under the label of "nucleation-condensation" (Dagett and Fersht, 2003)
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The first is that special tuning of nonnative interactions may contribute significantly to rapid folding; they stabilize the hypergutter-potentials that keep diffusive search dimensions under control
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, 1998; van Gunsteren et al
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Freed eggs were patted dry, weighed (nearest 0
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As illustrated in Figure 8, the absolute fecundity for a postfertilization 6-year-old black rockfish was only 58% of the estimated absolute fecundity for a prefertilizalion fish of the same age
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Dihydrocytochalasin B enhances transformining growth factor-beta-induced reexpression of the differentiated chondrocyte phenotype without stimulation of collagen synthesis
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