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Interestingly, no significant spectral changes were detected up to 1 M GdnHCl, whereas an increase in reactivity of one thiol group of GR to DTNB was observed at this concentration of GdnHCl (Fig
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Thus the β-sheet on the surface of the catalytic domain, Which is exposed to water in native ACYI, might unfold first
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Variability in quaternary association of proteins with the same tertiary fold: a case study and rationalization involving legume lectins
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We then "roll an N-sided die" to choose a residue whose torsion angles are to be altered
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American Institute of Physics, New York
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This work was supported by Projects CTQ2004-0771 ft from the Spanish Ministerio de Educación y Ciencia (MEC) to J
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Estefanía Hurtado-Gómez,* Gregorio Fernández-Ballester,* Harald Nothaft,[dagger] Javier Gómez,* Fritz Titgemeyer,[dagger] and José Luis Neira*[double dagger] * Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Alicante, Spain; [dagger] Lehrstuhl für Mikrobiologies, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; and [double dagger] Biocomputation and Complex Systems Physics Institute, Zaragoza, Spain Submitted October 31, 2005, and accepted for publication March 7, 2006
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As a result, disks containing larger proteins have lower unfavorable entropic contribution TΔS* to their kinetic stability ΔG* = ΔH*-TΔS*
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The remarkable size may result from both the number of monomers involved, and the fact that insulin aggregation intermediates are rather bulky and swollen with water (Dzwolak et al
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From the adult osteological descriptions by Herrera and Cousseau (1996) and Gosztonyi and Kuba, (2) we determined that the larvae studied were P
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