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The molten globule state
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Apparently, highly denatured states are to be viewed as embryos of native states since it is expected that native-like local and/or nonlocal signals are sampled with statistically significant probability in the denatured-state ensemble (10,130,131)
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and thus, it was dominated by the emission of the sole tryptophan residue
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When ANS binds to solvent-exposed hydrophobia patches, its quantum yield is enhanced and the maximum of emission is shifted from 520 nm to 480 nm (39,40)
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A similar reasoning can be used to explain the outcome of the effectors
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A receptor for phosphatidylserine-specific clearance of apoptotic cells
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Large-amplitude thermal fluctuations, requiring adequate protein hydration, have been shown to be mandatory for the function of bacteriorhodopsin, the light-driven proton pump in the purple membrane of Halobacterium salinarum (7)
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Prefibrillar amyloidogenic oligomers and protofibrils of misfolded TTR were generated in vitro through induction of the molten globule type A-state from acid unfolded TTR through the addition of NaCl
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The same is true for DCVJ (Fig
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Once protein unfolding reached completion in the first jump, the sample was cooled and incubated at 25°C for 1000 s, which was sufficient for completion of the helical refolding (as indicated by flattening of the Θ^sub 222^(t)) but not for the disk reconstitution (as indicated by DSC, EM, and gel electrophoresis)
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For simplicity we assume that the kinetics of each diffusive search is single exponential with characteristic time τ
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324OB-10/98 Presencew/d66OB-09/99 17
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Age truncation, an inevitable result of fishing, can increase recruitment variability by reducing the length of the spawning season or by selectively removing older, more fit individuals from the population
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Hence, the delistings policy produced savings of about $400,000 annually (10 percent x $4,000,000)
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"It's not a concern if the owner uses a legitimate online pharmacy and mails in a prescription from their veterinarian, who is monitoring the animal," she says
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About 40 generic drug makers, comprising nearly one-quarter of the total number of pharmacy product exhibitors, attended the conference
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Also speaking on behalf of community pharmacy were McKesson's senior managers
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"If this industry partnered" more effectively among its own members and with its pharmaceutical suppliers in the search for more recognition and payment for critical patient care services, he added, "We would be unstoppable
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economy matured and diversified, mill owners, bankers, and storeowners lobbied for the demise of lotteries in the hopes that citizens would spend their money in a more productive fashion
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The National Opinion Research Center (NORC), at the University of Chicago, reports that the percentage of American men who have ever gambled rose to 88 percent in 1998, up from 75 percent in 1975
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